Sjögren's Syndrome is a chronic autoimmune inflammatory disorder that destroys the salivary and lacrimal glands, leading to persistent symptoms of dry mouth (xerostomia) and dry eyes (keratoconjunctivitis sicca). It predominantly affects women between 40 and 60 years of age. Parotid gland enlargement occurs in approximately one-third of patients. Sjögren's Syndrome may occur alone as a primary form, or as a secondary form that complicates other diseases such as rheumatoid arthritis and systemic lupus erythematosus. Patients may also experience systemic manifestations, such as fatigue, arthritis, dental caries, vasculitis, pulmonary disease, neuropathy, and autonomic nervous system dysfunction that may accompany exocrine gland involvement. Patients with these systemic manifestations are at higher risk for lymphoma. Schirmer's test may be used to measure aqueous tear production using a strip of sterile filter paper. Less than 5 mm of wetting in 5 minutes is a positive result and supports a diagnosis of Sjögren's Syndrome. Serologic testing demonstrates positive ANA, Ro (SSA) and La (SSB) antibodies, and rheumatoid factor.